Nitroglycerin's primary mechanism is smooth muscle relaxation in blood vessels, leading to vasodilation.

Nitroglycerin gel works by releasing nitric oxide (NO), which activates an enzyme (guanylyl cyclase) that leads to
smooth muscle relaxation in blood vessels. This vasodilation widens blood vessels, increasing blood flow and
oxygen delivery, which is beneficial in autoimmune conditions that involve vasospasm (muscle spasms in blood
vessels). Nitroglycerin (NTG) is a potent smooth muscle relaxant and improves vascular flow. Acts on smooth
muscles of the blood vessels and other tissues, resulting in vasodilatation of the arteries and veins, thus improving the blood flow in cases of vasospasm or tissue ischemia.

Mechanism of Action: Precision Vasodilation 

Nitroglycerin gel delivers nitroglycerin, a potent vasodilator, directly to the site of need. Its targeted mechanism of action provides localized relief with minimal systemic exposure.

1. NO Release: Nitroglycerin is metabolized within vascular smooth muscle cells to release Nitric Oxide (NO).
2. Enzyme Activation: NO activates the enzyme guanylyl cyclase.
3. cGMPProduction: Guanylyl cyclase increases intracellular levels of cyclic guanosine
   monophosphate (cGMP).
4. Muscle Relaxation: Elevated cGMPinhibits calcium entry, leading to
   dephosphorylation of myosin light chains, resulting in smooth muscle relaxation and vasodilation.